• Atherosclerosis is a preventable disorder.
• LDL-C plays a central role in Atherosclerosis, Epidemiological, Observational studies, Genetic studies and randomized control trials have shown the impact of LDL as the Culprit.
• The more the reduction of LDL-C seen in the primary and secondary prevention trials by using statins either moderateor high-dose more benefit that was witnessed in CV reduction both in morbidity and mortality.
• Hence, our prime focus should be lowering LDL-C and keeping it low throughout our life.
• LDL-C:
• Lower the better
• Earlier the better
• Longer the better.
• LAI recommendation in 2020:
• For high risk <70 mg/dL
• Very high risk <50 mg/dL.

Introduced extreme risk group

Extreme risk Category A:

• Requires <50 mg/dL
• Optional <30 mg/dL

Extreme risk Category B: <30 mg/dL

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